Apparatus for detecting and quantifying clot lysis and establishing optimum medication and dosages
AssigneeThe Cleveland Clinic Foundation
InventorFrederick V. Lucas
Life of this patent
Estimating the term…
Abstract
A method and apparatus for detecting clot lysis, comprising allowing a blood sample containing a plasminogen activator to traverse a capillary track, wherein the capillary track contains a reagent capable of initiating blood clotting and the sample contacts the reagent as the sample flows through the track, the capillary track being of sufficient length and sufficiently small volume to allow blood to clot in the track before the sample reaches the end of the track and while a reserve sample volume remains available for continued capillary flow; allowing the sample to clot in the capillary track; and measuring time required for the sample to resume flowing as a measure of clot lysis.
Claims8
An analytical device for measuring clot lysis time of blood comprising:
- a housing containing a chamber including an inlet port and, a permeable tube section constructed so as to contain a blood clot and positioned within a reaction chamber, a first exit port, a first inlet capillary unit for independently pumping blood from said first inlet portion to said permeable tube section, and a first exit capillary unit positioned between and operatively connected to said reaction chamber unit and said first exit port for independently pumping blood from said reaction chamber unit to said first exit port;
- wherein said inlet port, first inlet capillary unit, said permeable tube section, first exit capillary unit, and exit port are present in a continuous first capillary pathway and said first pathway containing a reagent to affect blood clotting;
- said housing further containing a second chamber including a second inlet port connected by second capillary means in fluid communication with said reaction chamber, a second exit capillary means connecting said reaction chamber and a second exit port in a second continuous capillary pathway whereby a second blood supply may be drawn through said inlet port to said reaction chamber into contact with a slot contained in said permeable tube section, and thence to said outlet port.
Dependencies are inferred from the claim text.