High performance chromatography
AssigneeAlcoa Company of America
InventorGwoChung Lin
Life of this patent
Estimating the term…
Abstract
The invention includes a process for performing high performance liquid chromatography in the reverse phase. The present process for high performance separations by liquid chromatography uses a separations media, including separations packing materials for packed column separations, of polybutadiene coated and crosslinked on a surface of generally spherical metal oxide/hydroxide support particles comprising crystals of metal oxide/hydroxide with the crystals extending radially outward from a central core region and having a shape selected from principally acicular to principally lamellar. It has been found that liquid chromatography using the process of the present invention works particularly well in separating basic, nitrogen-containing compounds.
Claims18
A process for separating a compound by liquid chromatography comprising:
- (a) introducing a liquid feed stream containing at least one compound into contact with a stable polybutadiene on an alumina/aluminum hydroxide comprised of generally spherical alumina/aluminum hydroxide support particles comprising crystals of alumina/aluminum hydroxide with the crystals extending radially outward from a central core region and having a shape selected from principally acicular to principally lamellar;
- and
- (b) separating said basic compound by liquid chromatography to form a purified product stream of said compound.
A process for separating a compound in a liquid chromatography column comprising:
- (a) introducing a liquid feed stream containing at least one basic, nitrogen-containing compound into a column containing a packing material of polybutadiene coated and crosslinked on an alumina comprised of generally spherical metal oxide/hydroxide support particles comprising crystals of metal oxide/hydroxide with the crystals extending radially outward from a central core region and having a shape selected from principally acicular to principally lamellar;
- and
- (b) separating said compound by liquid chromatography in said packed bed to form a purified product stream of said compound.
A process for the separation of at least two basic, nitrogen-containing compounds in a liquid chromatography column comprising:
- (a) introducing a liquid feed stream containing at least one basic, nitrogen-containing compound into a column containing a packed bed of stable polybutadiene in a homogeneous, uniform film layer coated and crosslinked on an alumina of generally spherical metal oxide/hydroxide support particles comprising crystals of metal oxide/hydroxide with the crystals extending radially outward from a central core region and having a shape selected from principally acicular to principally lamellar;
- and
- (b) separating said basic compound by reverse phase liquid chromatography in said packed bed to form a purified product stream of said basic compounds.
Dependencies are inferred from the claim text.