Back to results
US 5,206,420 AGranted
Process for the preparation of succinylcholine halides
AssigneeHafslund Nycomed Pharma Aktiengesellschaft
InventorsWalter Raml, Gunther Eichberger
Life of this patent
Estimating the term…
Abstract
Preparation of succinylcholine halides of formula I: ##STR1## by reacting dialkyl succinates with an excess dimethylaminoethanol in the presence of an alkali metal alcoholate or alkali metal amide catalyst and then reacting the resulting bis(2-dimethylaminoethyl) succinates with methyl halides.
Claims7
A process for the preparation of a succinylcholine halide of formula I:
- ##STR5## in which X is chlorine, bromine or iodine, characterized in that a dialkyl succinate of formula II:
- ##STR6## in which R.sub.1 is (C.sub.1 -C.sub.4))-alkyl, is treated with an excess of dimethylaminoethanol in the presence of alkali metal alcoholates or amides as a catalyst, the alcohol formed in the reaction being distilled off continuously, excess dimethylaminoethanol being recovered and the catalyst then being inactivated and filtered off, after which the resulting bis(2-dimethylaminoethyl) succinate of formula III:
- ##STR7## is reacted with methyl halides to give a compound of formula I.
A process according to clam 1, characterized in that the molar ratio of the compound of formula II to the dimethylaminoethanol is between 1:2.5 and 1:40, preferably between 1:7 and 1:10.
Dependencies are inferred from the claim text.