Actinonin derivatives and pharmaceutically acceptable salts thereof
AssigneesZaidan Hojin Biseibutsu Kagaku Kai, Meiji Seika Kaisha, Ltd.
InventorsSeiji Shibahara, Yoshiyuki Koyama, Shigeharu Inoue, Mitsugu Hachisu, Shinichi Kondo, Takaaki Aoyagi, Tomio Takeuchi
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Abstract
A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): ##STR1## wherein R.sup.1 is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups; and R.sup.2 is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.
Claims6
An actinonin derivative represented by general formula (I):
- ##STR11## wherein R.sub.1 denotes sulfoxymethyl group or a substituted carboxyl group selected from carboxamide and hydroxyaminocarbonyl groups, and R.sup.2 denotes hydroxyl group, an alkoxy group, hydroxyamino group or sulfoxyamino group, and a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.