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US 5,206,371 AGranted
Quaternary pyridinium compounds
AssigneeGeorgia Tech Research Corporation
InventorsJames C. Powers, Sheldon W. May, Maria A. Hernandez, Steve Thornton, Jan Glinski
Life of this patent
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Abstract
Quaternary pyridinium compounds, their use in inhibiting acetylcholinesterase, their roles in the prophylaxis and treatment of organophosphate poisoning, their roles in anticholinesterase therapy and their roles as agents mimicking or opposing the actions of the natural neurotransmitter acetylcholine.
Claims1
A compound of the group consisting of the formulas:
- ##STR12## with any counterion to make pharmaceutically acceptable salts, wherein Z is selected from the group consisting of C.sub.1-6 alkyl, C.sub.1-6 alkyl with an attached phenyl group, C.sub.1-6 alkyl with an attached naphtyl group, C.sub.1-6 alkyl with two attached phenyl groups, C.sub.1-6 alkyl with an attached phenyl group mono, di, or trisubstituted with J, C.sub.1-6 alkyl with two attached phenyl groups mono, di, or trisubstituted with J, C.sub.1-6 alkyl with an attached naphtyl group mono, di, or trisubstituted with J,
- wherein J is selected from the group consisting of halogen, COOH, OH, CN, NO.sub.2, NH.sub.2, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylamine, C.sub.1-6 alkyl--O--CO--,C.sub.1-6 alkyl--O--CO--NH--C.sub.1-6 alkyl--NH--CO--NH--, C.sub.1-6 alkyl--NH--CO--NH--, C.sub.1-6 alkyl--NH--CO--O, C.sub.1-6 alkyl NH--CO--(C.sub.1-6 alkyl).sub.2 N--CO--, wherein X is selected from the group consisting of OH, C.sub.1-6 alkyl--NH--CO--O--, (C.sub.1-6 alkyl).sub.2 --N--CO--O--, C.sub.1-6 fluoroalkyl--NH--CO--O, (C.sub.1-6 fluoroalkyl).sub.2 --NH--CO--O--,
- R.sub.5 is selected from the group consisting of C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkyl with an attached phenyl group, C.sub.1-6 alkyl with an attached phenyl group mono, di, or trisubstituted with K, C.sub.1-6 alkyl with an attached naphthyl group, C.sub.1-6 alkyl with an attached naphthyl group mono, di, or trisubstituted with K,
- wherein R.sub.6 is selected from the group consisting of H, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkyl with an attached phenyl group, C.sub.1-6 alkyl with an attached phenyl group mono, di, or trisubstituted with K
- wherein K is selected from the group consisting of halogen, COOH, OH, CN, NO.sub.2, NH.sub.2, C.sub.1-6 alkyl--, C.sub.1-6 alkoxy, C.sub.1-6 alkylamine, C.sub.1-6 alkyl--O--CO--, C.sub.1-6 O--CO--NH--, (C.sub.1-6 alkyl--NH--CO--NH, C.sub.1-6 alkyl--NH--CO--O--, C.sub.1-6 alkyl NH--CO, (C.sub.1-6 alkyl).sub.2 N--CO--,
- wherein B is selected from the group consisting of H,C.sub.1-6 alkyl.
3 more elements
Dependencies are inferred from the claim text.