Preparation of optically active spiro-hydantoins
AssigneePfizer Inc.
InventorFrank J. Urban
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Abstract
This invention relates to the preparation of preparing optically-active asymmetric spiro-hydantoin compounds, which are known to be of value in the medical control of certain chronic diabetic complications arising from diabetes mellitus. This invention also includes within its scope certain corresponding novel amino and hydantoic acid compounds and the cinchonine salt of optically active hydantoic acid, which are used as intermediates in the aforesaid process.
Claims14
The method of preparing a compound of the formula ##STR11## comprising reacting a compound of the formula ##STR12## with acid at an elevated temperature.
The method of preparing a compound of the formula ##STR19## comprising reacting a compound of the formula ##STR20## with an (+)-cinchonine followed by treatment with an acid.
A compound of the formula ##STR21##
A compound of the formula ##STR22##
A compound of the formula ##STR23##
A compound of the formula ##STR24##
Dependencies are inferred from the claim text.