Psychotropic heterobicycloalkylpiperazine derivatives
OwnerJames S. New, William L. Christopherinventors
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Abstract
A series of psychotropic heterobicycloalkylpiperazine derivatives having the structure ##STR1## wherein V is a 3- or 4-membered unsaturated chain, containing all carbon atoms when 4-membered, or when a 3-membered chain, V contains an oxygen or sulfur atom as one of the members; R is H or C.sub.1-4 alkyl; W is CH, N, CH.sub.2, or a chemical bond; X is CH, N, SO.sub.2, or CO, with the proviso that both W and X cannot simultaneously be N; and Z is a heteroaromatic ring system. These compounds are useful antipsychotic and/or anxiolytic agents.
Claims5
A compound of Formula I and its pharmaceutically acceptable acid addition salts thereof ##STR30## wherein V is ##STR31## in which one of Q.sup.1, Q.sup.2 or Q.sup.3 is an oxygen or sulfur atom and the other two Qs are carbon atoms bearing either a hydrogen atom or R which is a C.sub.1-4 alkyl group;
- W is N;
- X is CH;
- the dotted line accompanying the full line is a double bond;
- and
- Z is a heteroaromatic ring system selected from pyrimidine, 1,2-benzisothiazole, thieno[3,2-c]pyridine, and furo[3,2-c]pyridine.
The compound of claim 1, 6-Methyl-3-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]thieno[2,3-d]pyrimidi n-4(3H)-one.
The compound of claim 1, 6-Methyl-3-[3-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]thieno[2 ,3-d]-pyrimidin-4(3H)-one.
Dependencies are inferred from the claim text.