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US 5,206,356 AGranted
Inhibitors for alpha-L-fucosyl transferase
AssigneeChembiomed, Ltd.
InventorsJames M. Pierce, Ole Hindsgaul
Life of this patent
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Abstract
Synthetic glycosaminosyl transferase-V acceptors and inhibitors are disclosed. Minimal trisaccharide inhibitors and acceptors specific for GnT-V, which is associated with the ability of cells to metastasize are useful, in diagnosis and treatment of conditions characterized by metastatic cells.
Claims1
A compound useful in inhibiting the activity of alpha-L-fucosyl transferase of the formula
- 2-deoxy-beta-Gal(1-4)beta-GlcNAc-OY (3)
- wherein Y is a hydrocarbyl of 3-20C which is unsubstituted or is substituted with 1-2 substituents selected from the group consisting of alkoxy (1-4C).
Dependencies are inferred from the claim text.