CD-4/cytotoxic gene fusions
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsEdward A. Berger, Bernard Moss, Thomas R. Fuerst, Ira Pastan, David Fitzgerald, Tamio Mizukami, Vijay K. Chaudhary
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Abstract
A chimeric gene directing the synthesis of hybrid recombinant fusion protein in a suitable expression vector has been constructed. The fusion protein possesses the property of selective cytotoxicity against specific virus-infected cells. A CD4(178)-PE40 hybrid fusion protein has been made for selectively killing HIV-infected cells.
Claims9
A chimeric gene which encodes a hybrid protein, wherein the hybrid protein comprises a sequence of human CD4 containing a binding site for HIV gp120 linked to a sequence of Pseudomonas exotoxin A essential for cell toxicity.
Dependencies are inferred from the claim text.