Oligopetides with cyclic proline-analogous amino acids
AssigneeHoechst Aktiengesellschaft
InventorsStephan Henke, Dietrich Brocks, Volkmar Gunzlen-Pukall, Kari I. Kivirikko, Raili M. H. Myllyla
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AssigneeHoechst Aktiengesellschaft
InventorsStephan Henke, Dietrich Brocks, Volkmar Gunzlen-Pukall, Kari I. Kivirikko, Raili M. H. Myllyla
Estimating the term…
The invention relates to compounds of the formula I ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc represents an optionally substituted heterocyclic carbonyl compound; D represents NH, NCH.sub.3, O or CH.sub.2 ; E represents CHOH, CO, SO or optionally N-substituted C.dbd.NH; F represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for the preparation thereof, and to the use thereof as inhibitors of prolyl hydroxylase.
A compound of the formula ##STR28## in which A denotes (C.sub.1 -C.sub.8)-alkoxycarbonyl, in which one hydrogen atom is optionally replaced by (C.sub.6 -C.sub.12)-aryl, or
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