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US 5,206,260 AGranted
Hexahydropyrrolo[2,3-b]indole derivatives
AssigneeMerck & Co., Inc.
InventorsMartin Hichens, Hanumath G. P. Kari, Kamlesh P. Vyas
Life of this patent
Estimating the term…
Abstract
Mammalian metabilites of the known acetylchloinesterase inhibitor trimethyl-1,3a,8-hexahydro-1,2,3,3a,8,8a-pyrrol[2,3-b]indole-5(3aS,8aR) heptylcarbamate are themselves cholinesterase inhibitors useful in the treatment of various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease and are also useful as analgesic agents in the alleviation of pain.
Claims15
A compound of Formula I:
- ##STR10## or a pharmaceutically acceptable salt thereof, wherein:
- R.sup.1 is selected from the group consisting of:
- (1) --(CH.sub.2).sub.6 CH.sub.3
- (2) --C.sub.7 H.sub.14 OH,
- (3) --(CH.sub.2).sub.4 --CO.sub.2 H, and
- (4) --(CH.sub.2).sub.2 --CO.sub.2 H;
- R.sup.2 is --CH.sub.2 R.sup.8 ;
- R.sup.3 is --CH.sub.2 R.sup.9 ;
- R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are independently selected from:
- hydrogen and hydroxy;
- with the proviso that if R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are hydrogen, then R.sup.1 is other than --(CH.sub.2).sub.6 CH.sub.3.
8 more elements
Dependencies are inferred from the claim text.