Naphthalene derivatives
AssigneeCiba-Geigy Corporation
InventorMarc Lang
Life of this patent
Estimating the term…
Abstract
Compounds of formula I ##STR1## wherein the dotted line, Az, Z, R.sub.1 and R.sub.2 are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
Claims10
A compound of formula I ##STR11## wherein the dotted line indicates the presence or absence of an additional bond, Az is 1,2,4-triazolyl bonded by way of a ring nitrogen atom, said triazolyl being unsubstituted or substituted at carbon atoms by lower alkyl, aryl-lower alkyl, trifluoromethyl, lower alkoxy, halogen or hydroxy, Z is C.sub.3 -C.sub.8 cycloalkyl, aryl-lower alkyl, hydroxy, aryl-lower alkoxy, aryloxy;
- lower alkanoyloxy;
- amino;
- lower alkanoylamino;
- nitro, lower alkanoyl, arylcarbonyl, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkylcarbamoyl, N,N-di-lower alkylcarbamoyl, N-arylcarbamoyl, cyano, mercapto, lower alkylthio, lower alkylsulfonyl, sulfamoyl, N-lower alkylsulfamoyl or N,N-di-lower alkylsulfamoyl, and each of R.sub.1 and R.sub.2 independently of the other is hydrogen or one or more of the substituents selected from lower alkyl, trifluoromethyl, C.sub.3 -C.sub.8 cycloalkyl, aryl-lower alkyl, hydroxy, lower alkoxy, aryl-lower alkoxy, aryloxy;
- lower alkanoyloxy;
- halogen, amino;
- lower alkanoylamino;
- nitro, lower alkanoyl, arylcarbonyl, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkylcarbamoyl, N,N-di-lower alkylcarbamoyl, N-arylcarbamoyl, cyano, mercapto, lower alkylthio, lower alkylsulfonyl, sulfamoyl, N-lower alkylsulfamoyl or N,N-di-lower alkylsulfamoyl, with the provision that neither Z nor R.sub.2 is a hydroxy substituent in the 8-position, or a salt thereof;
- in which aryl is phenyl or naphthyl which may be unsubstituted or substituted by one or two substituents from the group consisting of lower alkyl, lower alkoxy, hydroxy, lower alkanoyloxy, nitro, amino, halogen, trifluoromethyl, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkylcarbamoyl, N,N-di-lower alkylcarbamoyl, cyano, lower alkanoyl, lower alkylsulfonyl, sulfamoyl, N-lower alkylsulfamoyl and N,N-di-lower alkylsulfamoyl.
Dependencies are inferred from the claim text.