Disphosphonic acid derivatives, processes for their production and pharmaceutical preparations containing these compounds
AssigneeBoehringer Mannheim GmbH
InventorsElmar Bosies, Frieder Bauss
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Abstract
The present invention concerns novel disphosphonates having the general formula I ##STR1## in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if desired, and which can also be partially hydrogenated, R.sub.1 -R.sub.7 each denote, independently of each other, hydrogen or C.sub.1 -C.sub.5 alkyl, X=denotes hydrogen, OH or the group --NR.sub.8 R.sub.9, in which R.sub.8 and R.sub.9 should each be, independently of each other, hydrogen or C.sub.1 -C.sub.5 alkyl, m and n denote, independently of each other, 0, 1 or 2, as well as their pharmacologically safe salts and optically active forms.
Claims6
Diphosphonates having the general formula I ##STR19## in which Het is selected from the group consisting of a pyrazolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, dithiazolyl and tetrazolyl ring as well as their dihydro and tetrahydro derivatives which ring can be partially hydrogenated and is unsubstituted or substituted at least once by C.sub.1 -C.sub.6 alkyl, halogen, amino or CF.sub.3,
- R.sub.1 -R.sub.7 are each independently hydrogen or C.sub.1 -C.sub.5 alkyl,
- X is hydrogen, OH or --NR.sub.8 R.sub.9, in which R.sub.8 and R.sub.9 are, independently hydrogen or C.sub.1 -C.sub.5 alkyl,
- m and n are independently 0, 1 or 2, and
- their pharmacologically safe salts and optically active forms.
Dependencies are inferred from the claim text.