2- and 3- amino and azido derivatives of 1,5-iminosugars
AssigneeG. D. Searle & Co.
InventorsIsh K. Khanna, Richard A. Mueller, Richard M. Weier
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Abstract
Novel derivatives of 1-deoxynojirimycin are disclosed which have amino or azido substituents at C-2 and/or C-3. These compounds are useful inhibitors of lentiviruses. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
Claims8
A compound selected from the group consisting of derivatives of 1-deoxynojirimycin having an azido substituent at C-2 represented by the formula ##STR14## wherein R=H, alkyl, and 4,4,4-trifluorobutyl
- X.sub.1 =N.sub.3 ;
- X.sub.2 =OH.
A compound selected from the group consisting of derivatives of 1- deoxynojirimycin having an amino substituent at C-3 represented by the formula ##STR15## wherein R=H;
- X.sub.1 =OH;
- X.sub.2 =NH.sub.2.
A compound selected from the group consisting of derivatives of 1-deoxynojirimycin having amino substituents at C-2 and C-3 represented by the formula ##STR16## wherein R=n-butyl;
- X.sub.1 =NH.sub.2 ;
- X.sub.2 =NH.sub.2.
Dependencies are inferred from the claim text.