Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
AssigneeThe Du Pont Merck Pharmaceutical Company
InventorJung-Hui Sun
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Abstract
This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione] and 2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione], processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat cancer in mammals.
Claims6
A compound, or a pharmaceutically acceptable salt thereof, which si selected from the group consisting of:
- (S,S)-2,2'-[1,2-ethanedylbis[imino(1-methyl-2,1-ethanediyl)]]-bis [5-nitro-1H-benz[de ]disoquinoline-1,3(2H)-dione];
- (Racemic+Meso)-2,2'-[1,2-ethanedylbis[imino(1-methyl-2,1-ethanediyl)]]-bis [5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione;
- (R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis [5-nitro-1H-benz[de ]isoquinoline-1,3(2H)-dione];
- (Meso)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis [5-nitro-1H-benz[de]isoquinoline-1,3)(2H)-dione];
- (S,S)-2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis [5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione];
- (Racemic+Meso)-2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis [5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione];
- (R,R)-2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro- 1H-benz[de]isoquinoline-1,3(2H)-dione];
- (Meso)-2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis [5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione].
The compound, or a pharmaceutically acceptable salt thereof, which is (R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis [5-nitro-1H-benz[de]isoquinoline-1,3(2l H)-dione].
Dependencies are inferred from the claim text.