Anxiolytic-R-n(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides
AssigneeA. H. Robins Company, Incorporated
InventorsMichel Langlois, Alain Renaud, Robert J. Naylor, Brenda Naylor
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AssigneeA. H. Robins Company, Incorporated
InventorsMichel Langlois, Alain Renaud, Robert J. Naylor, Brenda Naylor
Estimating the term…
Compounds of general formula I ##STR1## wherein: X represents oxygen or sulphur; each of R.sup.1 and R.sup.3 independently represents hydrogen or a C.sub.1 -C.sub.4 alkyl group; Ar represents: a phenyl ring optionally substituted by one, two or three C.sub.1 -C.sub.4 alkoxy groups and/or by one or two halogen atoms; a phenyl ring of the general formula ##STR2## wherein R.sup.2 represents halogen, 4,5-benzo, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.4 alkylcarbonyl or Am, wherein Am represents amino, methylamino or dimethylamino, R.sup.4 represents C.sub.1 -C.sub.8 alkyl, n is 1 or 2; or a pyrimidinyl moiety of the general formula ##STR3## wherein R.sup.5 is C.sub.1 -C.sub.4 alkyl; and their N-oxides and pharmaceutically acceptable salts are useful as anxiolytic agents. A preferred compound is R-(+)-4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide.
A compound of formula:
A pharmaceutical and/or veterinary composition comprising (a) a therapeutically effective amount of a compound of formula:
A method of controlling anxiety in warm blooded animals which comprises internally administering thereto an anxiolytic effective amount of a compound of formula I ##STR24## wherein:
Dependencies are inferred from the claim text.