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US 5,206,241 AGranted
Labdanes and process for their preparation
AssigneeHoechst Aktiengesellschaft
InventorsYatendra Khandelwal, Rajeshwari Kannan, Bansi Lal, Ramanujam Rajagopalan, Vijay A. Aroskar, deceased AliHussein N. Dohadwalla, Rashida A. Dohadwalla, Anis S. Dohadwalla, Samina A. Dohadwalla, Richard H. Rupp
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Abstract
Labdanes of the formula ##STR1## a process for their manufacture, pharmaceutical preparations containing an effective amount of these compounds and their use for the manufacture of a pharmaceutical preparation for treatment of cardiovascular diseases and high intraocular pressure.
Claims8
A compound having the formula ##STR42## wherein R is vinyl;
- R.sub.1 is hydrogen;
- R.sub.6 is --CO(CH.sub.2).sub.2 NX.sub.1 Y.sub.1, wherein X.sub.1 and Y.sub.1 are each methyl or X.sub.1 and Y.sub.1 form, together with the N atom to which they are bonded, a piperidine, morpholine, or N-methylpiperazine ring;
- and
- R.sub.7 is --COCH.sub.2 OZ.sub.1, wherein Z.sub.1 is methyl, ethyl, phenyl, or 4-chlorophenyl;
- and the optical and geometric isomers and pharmaceutically acceptable salts thereof.
2 more elements
A compound having the formula ##STR43## wherein R is vinyl;
- R.sub.1 is hydrogen;
- R.sub.6 is --COCH.sub.2 OCH.sub.3 ;
- and
- R.sub.7 is --CO(CH.sub.2).sub.2 NX.sub.1 Y.sub.1, wherein X.sub.1 and Y.sub.1 are each methyl or X.sub.1 and Y.sub.1 form, together with the N atom to which they are bonded, a piperidine, morpholine, or N-methylpiperazine ring;
- and the optical and geometric isomers and pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.