Nitrogen-containing spirocycles

A compound of structural formula:

• ##STR372## or a pharmaceutically acceptable salt thereof, wherein Ar.sup.1 is benzo;
• the ring system comprising X, Y and Z is a 5-, 6- or 7-membered ring system wherein X is CHOH or CO;
• Y is CH, a bond or (CR.sub.4 R.sub.5).sub.m ;
• and Z is --0--;
• wherein:
• R.sup.4 and R.sup.5 are independently
• a) hydrogen, or
• b) C.sub.1-6 alkyl;
• M is
• 1) --H,
• 2) --OH,
• 3) --O(C.sub.1-6 alkyl),
• 4) --CN,
• 5) --NHSO.sub.2 C.sub.1-6 alkyl,
• 6) --COOH,
• 7) --COOC.sub.1-6 alkyl,
• 8) --CONR.sup.12 R.sup.13, wherein R.sup.12 and R.sup.13 are independently
• a) hydrogen,
• b) C.sub.1-6 alkyl, or
• c) R.sup.12 and R.sup.13 taken together with the nitrogen atom to which they are attached represent a 5 or 6 membered saturated heterocyclic ring which may contain an additional heteroatom selected from N, S(O).sub.n or O, wherein n is 0-2, selected from the group consisting of pyrrolidine, morpholine, piperidine, piperazine or N-methylpiperazine,
• 9) --NR.sup.12 R.sup.13,
• 10) halo,
• 11) C.sub.5-8 cycloalkane,
• 12) C.sub.5-8 cycloalkene, or
• 13) ##STR373## wherein s is 1-3 and the R.sup.3 groups may be the same or different;
• R is --(CR.sup.4 R.sup.5).sub.m --Q--(CR.sup.4 R.sup.5).sub.q --, wherein R.sup.4 and R.sup.5 are as defined above, m and q are O, Q is a bond;
• R.sup.1, R.sup.2, and R.sup.3 are independently selected from:
• 1) hydrogen,
• 2) C.sub.1-6 alkyl, either unsubstituted or substituted with
• a) --NR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 are as defined above,
• b) --N(R.sup.5)COC.sub.1-6 alkyl,
• c) --NHSO.sub.2 (C.sub.1-6 alkyl),
• d) --CONR.sup.12 R.sup.13, wherein R.sup.12 and R.sup.13 are as defined above,
• e) --CO(C.sub.1-6 alkyl),
• f) --OH,
• g) --O(C.sub.1-6 alkyl),
• h) --O(C.sub.1-6 alkyl)--O--(C.sub.1-3 alkyl),
• i) --S(O).sub.n (C.sub.1-6 alkyl),
• j) imidazole,
• k) 2-imidazolidinone,
• l) 2-pyrrolidinone,
• m) --NH--C(NHR.sup.5).dbd.N--CN, or
• n) --NH--C(SR.sup.5).dbd.N--CN,
• 3) --OH,
• 4) C.sub.1-3 alkoxy, either unsubstituted or substituted with C.sub.1-3 alkoxy,
• 5) --N(R.sup.5)SO.sub.2 (C.sub.1-6 alkyl),
• 6) --N(R.sup.5)SO.sub.2 (CH.sub.2).sub.g CO.sub.2 H,
• 7) --N(R.sup.5)SO.sub.2 (CH.sub.2).sub.g CO.sub.2 C.sub.1-6 alkyl,
• 8) --NO.sub.2,
• 9) --N(R.sup.5)COC.sub.1-6 alkyl,
• 10) --N(R.sup.5)SO.sub.2 --C.sub.6 H.sub.4 --R.sup.4,
• 11) --N(R.sup.5)CO--C.sub.6 H.sub.4 --R.sup.4,
• 12) --NR.sup.4 R.sup.5,
• 13) halo,
• 14) --CO--C.sub.1-6 alkyl,
• 15) --CONR.sup.12 R.sup.13,
• 16) --CN,
• 17) --CO.sub.2 R.sup.5,
• 18) --C(R.sup.5).dbd.N--OR.sup.9,
• 19) benzoyl, either unsubstituted or substituted with C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halo, or hydroxy,
• 20) --N(R.sup.5)COO(C.sub.1-6 alkyl),
• 21) --N(R.sup.5)COO--phenyl either unsubstituted or substituted with C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or halo,
• 22) --N(R.sup.5)CONR.sup.4 R.sup.5,
• 23) --S(O).sub.n C.sub.1-6 alkyl,
• 24) --S(O).sub.n --C.sub.6 H.sub.4 --R.sup.4,
• 25) --CF.sub.3,
• 26) phenyl, either unsubstituted or substituted with C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halo or hydroxy,
• 27) imidazolyl,
• 28) --SO.sub.2 NR.sup.12 R.sup.13,
• 29) --N[S(O).sub.2 C.sub.1-6 alkyl][(CH.sub.2).sub.p CN], wherein p is 2-5,
• 30) --N(R.sup.5)--C(NR.sup.4 R.sup.5).dbd.N--CN, or
• 31) --N(R.sup.5)--C(SR.sup.5).dbd.N--CN;
• B is piperidine;
• and
• Ar.sup.2 is benzene or naphthalene;
• with the proviso that if Ar.sup.1 is benzo, and R.sup.1 and R.sup.2 are hydrogen, hydroxyalkyl or alkoxy, then M is other than unsubstituted phenyl or hydrogen.