Method for the treatment of malaria
OwnerRichard R. Tidwell, J. Dieter Geratz +4inventors
InventorsRichard R. Tidwell, J. Dieter Geratz, James E. Hall, Dennis E. Kyle, Max Grogl, Kwasi A. Ohemeng
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Abstract
A method for treating malaria which comprises to an afflicted host patient a therapeutically effective amount of a compound have the structure of formula I: ##STR1## wherein X is O or NH; R.sub.1 is H or two R.sub.1 groups on the same amidine group together represents --(CH.sub.2).sub.m --, wherein m=2, 3 or 4; R.sub.2 is H, NH.sub.2, Cl, NO.sub.2 ; R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and n=2-6 or a pharmaceutically acceptable salt thereof provided that when X is O, both R.sub.2 and both R.sub.3 can not be H.
Claims1
A method for treating malaria which comprises the to an afflicted host patient a therapeutically effective amount of a compound have the structure of formula I:
- ##STR7## wherein X is O or NH;
- R.sub.1 is H or two R.sub.1 groups on the same amidine group together represent --(CH.sub.2).sub.m --, wherein m.ltoreq.2,3 or 4;
- R.sub.2 is H, NH.sub.2, OCH.sub.3, Cl, NO.sub.2 ;
- R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and n=2-6 or a pharmaceutically acceptable salt thereof provided that when X is O, both R.sub.2 and both R.sub.3 can not be H.
Dependencies are inferred from the claim text.