Benzolactam analogs as antagonists of CCK

A compound of Formula I:

• ##STR6## wherein:
• R.sup.1 is H, halo, hydroxy, nitro, amino, cyano, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.4 -alkylamino, C.sub.1 -C.sub.4 -alkoxy;
• R.sup.2 is unsubstituted or mono-, di-, or trisubstituted C.sub.1 -C.sub.8 -straight- or branched-alkyl, where the substituents are selected from the group consisting of C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkyloxy, C.sub.1 -C.sub.4 -alkylamino, unsubstituted or mono-, di-, or trisubstituted phenyloxy or naphthyloxy unsubstituted or mono-, di-, or trisubstituted phenylthio or naphthylthio, unsubstituted or mono-, di-, or trisubstituted phenyl or naphthyl, and the substituents on the phenyloxy or naphtholoxy, the phenylthio or naphthylthio, the C.sub.6 - or C.sub.10 -aryl being selected from C.sub.1 -C.sub.8 -straight- or branched-alkyl, hydroxy, C.sub.1 -C.sub.4 -alkoxy, halo, nitro, amino, C.sub.1 -C.sub.4 -alkylthio or mono- or di-C.sub.1 -C.sub.4 -alkylamino;
• substituted carbonyl-C.sub.1 -C.sub.4 -alkyl, which carbonyl group is substituted with hydroxy, C.sub.1 -C.sub.8 -straight- or branched-alkoxy, C.sub.1 -C.sub.8 -straight- or branchedalkyl, unsubstituted or mono-, di-, or trisubstituted phenyl or naphthyl, unsubstituted or mono-, di-, or trisubstituted phenyl or naphthyl-C.sub.1 -C.sub.8 -alkyl, and unsubstituted or mono-, di-, or trisubstituted phenyl or naphthyl-C.sub.1 -C.sub.4 -alkoxy, where the substituents on the phenyl or naphthyl, the phenyl or naphthyl-C.sub.8 -alkyl or the phenyl or naphthyl-C.sub.1 -C.sub.4 -alkoxy are selected from the groups consisting of hydroxy, C.sub.1 -C.sub.8 -straight-or branched-alkyl, C.sub.1 -C.sub.4 -alkoxy, halo, cyano, nitro, amino, C.sub.1 -C.sub.4 -alkylthio, and mono- or di-C.sub.1 -C.sub.4 - alkylamino, or NR.sup.6 R.sup.7, where R.sup.6 and R.sup.7 are independently selected from hydrogen, C.sub.1 -C.sub.6 -straight- or branched-alkyl, unsubstituted or mono-, di-, or trisubstituted-carboxy-C.sub.1 -C.sub.8 -straight- or branched-alkyl, or unsubstituted or mono-, di-, or trisubstituted-carboxamido-C.sub.1 -C.sub.8 -straight- or branched-alkyl, wherein the substituents on the carboxy-C.sub.1 -C.sub.8 -straight- or branched-alkyl or on the carboxamido-C.sub.1 -C.sub.8 -straight- or branched-alkyl are selected from the group consisting of unsubstituted or mono-, di-, or trisubstituted phenyl or naphthyl, unsubstituted or mono-, di- or trisubstituted phenyl or naphthyl-C.sub.1 -C.sub.8 -alkyl, unsubstituted or mono-, di-, or trisubstituted phenyl or naphthyl-C.sub.10 -aryl-C.sub.1 -C.sub.4 -alkoxy, where the substituents on the phenyl or naphthyl, the phenyl or naphthyl-C.sub.1 -C.sub.8 -alkyl or the phenyl or naphthyl-C.sub.1 -C.sub.4 -alkoxy are selected from the group consisting of hydroxy, C.sub.1 -C.sub.8 -straight- or branched-alkyl, C.sub.1 -C.sub.4 -alkoxy, halo, nitro, cyano, amino, C.sub.1 -C.sub. 4 -alkylthio, and mono- or di-C.sub.1 -C.sub.4 -alkylamino;
• R.sup.3 and R.sup.4 are independently unsubstituted or mono-, di- or trisubstituted phenyl or naphthyl, where the substituents are selected from the group consisting of C.sub.1 -C.sub.8 -straight- or branched-alkyl, hydroxy, C.sub.1 -C.sub.4 -alkoxy, halo, nitro, amino, cyano, C.sub.1 -C.sub.4 -alkylthio and mono-or di-C.sub.1 -C.sub.4 -alkylamino;
• C.sub.3 -C.sub.10 -cycloalkyl;
• C.sub.3 -C.sub.10 -cycloalkyl-C.sub.1 -C.sub.4 -alkyl;
• C.sub.1 -C.sub.6 -straight- or branched-alkyl-Q-(CH.sub.2)m, where m is 2 to 4 and Q is O, S, SO, SO.sub.2, --HC.dbd.CH--, or substituted amino, wherein the substituent is hydrogen, C.sub.1 -C.sub.8 -straight- or branched-alkyl, unsubstituted or mono-, di- or trisubstituted C.sub.6 - or C.sub.10 -aryl, or C.sub.9 -C.sub.12 -benzofused cycloalkyls;
• n is 0-3;
• or the optical isomers or pharmaceutically acceptable salts thereof.