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US 5,206,233 AGranted
Substituted thiazepines as central nervous system agents
AssigneeWarner-Lambert Company
InventorsWilliam J. Smith, III, Lawrence D. Wise, David J. Wustrow
Life of this patent
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Abstract
Substituted thiazepines are described as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic and antidepressant agents as well as for treating cerebral ischemia or cerebral infarction.
Claims6
A compound of Formula I ##STR29## wherein R is hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, amino, nitro, trifluoromethyl, or cyano;
- and
- R.sup.1 is ##STR30## wherein R.sup.2 is hydrogen, lower alkyl, --(CH.sub.2).sub.n --R.sup.3 wherein R.sup.3 is ##STR31## and n is an integer of 1, 2, 3, 4, or 5;
- ##STR32## wherein R.sup.3 and n are as defined above or ##STR33## wherein m is an integer of 2, 3, 4, 5, or 6;
- and corresponding optical isomers thereof;
- or a pharmaceutically acceptable acid addition salt thereof.
2 more elements
Dependencies are inferred from the claim text.