Method for inhibiting heparanase activity
AssigneeYeda Research and Development Co. Ltd.
InventorsIsrael Vlodavsky, Amiram Eldor, Yaakov Naparstek, Irun Cohen
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Abstract
Heparanase activity in a patient may be inhibited by administering an effective heparanase-inhibiting amount of heparin or an effective chemically modified derivative of heparin which inhibits heparanase activity. Such derivatives are preferably N-desulfated, N-acetylated heparin or O-desulfated, N-acetylated heparin. By means of this invention, allograft rejection may be prevented or delayed and autoimmune diseases such as arthritis may be alleviated and treated.
Claims9
A method for inhibiting heparanase activity comprising administering to a patient in need thereof an effective heparanase inhibiting amount of a composition consisting essentially of an active ingredient selected from the group consisting of heparin and an effective chemically modified derivative thereof which inhibits heparanase and a pharmaceutically acceptable carrier.
A method for preventing or delaying allograft rejection comprising administering to a human patient subject to said rejection an effective amount of a compound selected from the group consisting of heparin and effective chemically modified derivatives of heparin which inhibit heparanase in a daily dosage ranging from about 0.014 mg to about 0.14 mg per kg of patient body weight.
Method for alleviating and treating an autoimmune disease comprising administering to a human patient suffering from such disease an effective amount of a compound selected from the group consisting of heparin and effective chemically modified derivatives of heparin which inhibit heparanase in a daily dosage ranging from about 0.014 mg to about 0.14 mg per kg of patient body weight.
Dependencies are inferred from the claim text.