Soluble and stable sources of tyrosine, cysteine and glutamine for total parenteral nutrition
AssigneeResearch Corporation Technologies, Inc.
InventorMary A. Hilton
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Abstract
The present invention provides soluble and/or stable sources of tyrosine, cysteine and glutamine for use in total parenteral nutrition (TPN), as well as a gradual release source of glutamic acid. In particular, these sources are gamma-glutamyltyrosine (.gamma.-GluTyr) gamma-glutamylcysteine derivatives (.gamma.-GluCys) and gamma-glutamylglutamine (.gamma.-GluGln). This invention provides TPN formulations, and methods of formulating and using such solutions containing .gamma.-GluTyr, .gamma.-GluCys and/or .gamma.-GluGln to provide adequate nutritional levels of tyrosine, cysteine or glutamine during TPN.
Claims42
A method for total parenteral nutrition (TPN) of a patient which comprises administering to said patient .gamma.-glutamyltyrosine in a TPN solution in an amount effective to provide a sufficient nutritional level of free tyrosine in said patient.
A method for total parenteral nutrition (TPN) of a patient which comprises administering to said patient .gamma.-glutamylcysteine in a TPN solution in an amount effective to provide a sufficient nutritional level of cysteine in said patient.
A method for total parenteral nutrition (TPN) of a patient which comprises administering to said patient a TPN solution comprising at least one of the peptides .gamma.-glutamyltyrosine or .gamma.-glutamylcysteine effective in an amount to provide sufficient nutrition in said patient.
A composition for total parenteral nutrition comprising an effective amount of each of at least one of the peptides .gamma.-glutamyltyrosine to provide a sufficient nutritional level of tyrosine or .gamma.-glutamylcysteine to provide a sufficient nutritional level of cysteine or a combination of both.
A composition for total parenteral nutrition comprising an effective amount of .gamma.-glutamyltyrosine to provide a sufficient nutritional level of tyrosine.
A composition for total parenteral nutrition comprising an effective amount of .gamma.-glutamylcysteine to provide a sufficient nutritional level of cysteine.
Dependencies are inferred from the claim text.