US 5,206,156 AGranted

Process for the preparation of a particulate antimicrobial product, antimicrobial product obtained and applications thereof

AssigneeBio Serae Laboratoires S.A.

InventorsDaniel Samain, Frederique Nguyen, Michel Degre

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Abstract

The invention relates to a process for the preparation of a particulate antimicrobial product from the LP system of the lactoperoxidase enzyme/oxygen donor/oxidizable substrate (if needed). The process comprises bonding the lactoperoxidase enzyme to a particulate carrier comprising a polysaccharide nucleus, a first lipidic layer and a second phospholipidic layer in such a manner that the enzyme molecules are inserted into this second layer and/or into the first layer. The product according to the invention is obtained by then conditioning in a non-aqueous medium the aforesaid particulate vector and the molecules of the LP system not integrated into said vector. The process of the invention permits adjusting the diffusability of the product and its mobility as a function of the intended applications, without destruction of the LP system.

Claims13

Dependent claims

A process for preparation of a particulate antimicrobial product using the antimicrobial LP system of lactoperoxydase enzyme/oxygen donor/oxidizable substrate, wherein the oxygen donor is a peroxide, a reactive substance, or micro-organisms, for modifying the physiochemical properties of the LP system and providing the LP system in the form of particles insoluble in an aqueous medium, the process comprising:

bonding at least the lactoperoxydase enzyme of the LP system to a particulate vector, each particle of said particulate vector comprising a nucleus formed of a hydrophilic polysaccharidic polymer, a first lipidic layer chemically bound to the nucleus by hydroxy functional groups or derivatives thereof, and a second phospholipidic layer so that the molecules of enzyme are inserted into the second phospholipidic layer and/or into the first lipidic layer,
introducing said particulate vector into a non-aqueous medium.

Dependencies are inferred from the claim text.