Microorganism for selective production of a specific compound of avermectin and a method for selective production thereof
AssigneeThe Kitasato Institute
InventorsSatoshi Omura, Haruo Ikeda
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Abstract
A microorganism for selective production of a specific compound of avermectin having one or more of the following properties: specific accumulation of avermectin compound "a", effective incorporation of isoleucine or its keto acid (3-methyl-2-oxovaleric acid) into avermectin molecule, and markedly suppressed incorporation of valine or its keto acid (2-oxoisovaleric acid) into avermectin molecule.
Claims7
A biologically pure culture of the microorganism Streptomyces avermitilis, wherein the culture is capable of producing essentially only avermectin compound "a" and wherein further the culture retains the ability to degrade isoleucine or its keto acid (3-methyl-2-oxovaleric acid) but has a decreased ability to degrade valine or its keto acid (2-oxoisovaleric acid) in the avermectin biosynthetic pathway.
Dependencies are inferred from the claim text.