Medicament and its production and use in the treatment of pain, inflammation and fever in man and animals
AssigneePAZ Arzneimittel-Entwicklungsgesellschaft mbH
InventorsGerd Geisslinger, Kay Brune
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Abstract
The present invention provides a medicament for the treatment of painful and/or inflammatory diseases and/or of fever with flurbiprofen, wherein the previously separated enantiomers of flurbiprofen are worked up in a ratio of 99.5-0.5% to 0.5-99.5%, in combination with conventional pharmaceutical carriers and adjuvants, to give a medicament.
Claims21
A medicament effective for the treatment of a disease characterized by pain or inflammation which comprises
- (a) a mixture of the previously-separated R(-) and S(+) enantiomers of flurbiprofen and
- (b) a pharmaceutically acceptable carrier, wherein the ratio of said R(-) and S(+) enantiomers of flurbiprofen is from about 99.5:0.5% to 0.5:99.5% wherein the medicament further comprises 2-10% of a release agent.
A medicament as claimed in claim further comprising an adjuvant.
A medicament as claimed in claim wherein said ratio is from about 95:5% to 5:95%.
A medicament as claimed in claim 10, wherein said flurbiprofen enantiomers are in the form of flurbiprofen salts or aluminum compounds.
A method for treating a human or animal patient suffering from a disease characterized by pain, comprising the step of administering to said patient a medicament comprising (a) an analgesically effective amount of a mixture of the previously separated R(-) and S(+) enantiomers of flurbiprofen, and mixture containing 50 to 99.5% R(-)-flurbiprofen and 50 to 0.5% S(+)-flurbiprofen and (b) a pharmaceutically acceptable carrier wherein the medicament further comprises 2-10% of a release agent.
A method for treating a human or animal patient suffering from a disease characterized by inflammation, comprising the step of administering to said patient a medicament comprising (a) an antiphlogistically effective amount of a mixture of the previously separated R(-) and S(+) enantiomers of flurbiprofen, said mixture containing 50 to 99.5% S(+)-flurbiprofen and 50 to 0.5% R(-)-flurbiprofen and (b) a pharmaceutically acceptable carrier wherein the medicament further comprises 2-10% of a release agent.
Dependencies are inferred from the claim text.