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US 5,206,027 AGranted
Amphipathic compound and liposome comprising the same
AssigneeFuji Photo Film Co., Ltd.
InventorHiroshi Kitaguchi
Life of this patent
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Abstract
An amphipathic compound, which includes a succinic acid moiety and an amino acid moiety and is designed so as to form a stable unilayer liposome, and a negatively charged liposome comprising said amphipathic compound as a membrane-component are disclosed. The amphipathic compound of the present invention gives liposomes which minimize the leakage of a drug encapsulated therein and scarcely undergo association, aggregation or precipitation.
Claims4
A compound represented by formula (I), (II) or (III):
- ##STR26## wherein R.sup.1 and R.sup.2 each represents a straight chain or branched alkyl or acyl group having 8 to 24 carbon atoms, which has or does not have substituents or unsaturated groups;
- R.sup.3n, R.sup.3(n+1), R.sup.3m and R.sup.3(m+1) each represents a side chain residue of an .alpha.-amino acid;
- m represents an integer of from 0 to 5;
- n is an integer of from 1 to 5;
- the compound is racemic or optically active and the terminal carboxyl group may form a salt with a cation.
2 more elements
Dependencies are inferred from the claim text.