Enhancement of immune response
AssigneeVirginia Commonwealth University
InventorRoger Loria
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Abstract
The present invention provides an improved means for regulating the immune response, for ameliorating effects of stress, and for avoiding untoward effects of chemotherapy or exposure to irradiation by administration of androstenediol (AED) and androstenetriol (AET). The improved means of regulating immune response can be utilized in treating infectious diseases and immune diseases such as diabetes and chronic fatigue syndrome, both diseases now considered to be immune response related syndromes.
Claims24
A method of enhancing protective immune response and treating complications accompanying immune suppression in a mammal by administration of an immune response enhancing effective amount of a composition containing at least one compound of the structure:
- ##STR4## wherein R.sub.1 may be H, alkenyl of 2-8 carbons, alkyl of 1-8 carbons, benzyl, phenyl or COR.sub.2, wherein R.sub.2 is H, alkyl of 1-8 carbons, alkenyl of 2-8 carbons, benzyl, or phenyl wherein the phenyl moiety may have up to three substituents selected from the group consisting of hydroxy, carboxy of 1-4 carbons, halo, alkoxy of 1-4 carbons, alkyl of 1-4 carbons, and alkenyl of 2-4 carbons.
A method of claim 2 wherein the composition is administered using a patch or implant.
Dependencies are inferred from the claim text.