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US 5,205,929 AGranted
High stability porous zirconium oxide spherules
AssigneeRegents of the University of Minnesota
InventorsPeter W. Carr, Eric F. Funkenbusch, Martin P. Rigney, Patrick L. Coleman, Douglas A. Hanggi, Wes A. Schafer
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Abstract
The present invention provides a stable stationary phase for chromatography which comprises porous ZrO.sub.2 spherules coated with a cross-linked polymer coating wherein said coated spherules have a pore size from about 20-500 .ANG. and a particle diameter range of about 0.5-500 microns, and are stable in basic media to pHs of up to about 14.
Claims3
A bed comprising porous ZrO.sub.2 spherules of about 0.5-500 microns in diameter, about 1-200 m.sup.2 /g surface area and of about 20-500 .ANG. pore diameter;
- wherein said spherules are substantially stable in an aqueous solution of a pH of about 1-14, and comprise an immobilized protein.
Dependencies are inferred from the claim text.