Fluorophore assisted carbohydrate electrophoresis diagnosis
AssigneeGlyko, Inc.
InventorJohn C. Klock, Jr.
Life of this patent
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Abstract
The subject invention provides methods and kits for conveniently diagnosing various physiological conditions that produce altered levels of specific carbohydrates, known as diagnostic carbohydrates. Measurement of the levels of the diagnostic carbohydrates is performed by fluorophore assisted carbohydrate electrophoresis. Physiological conditions of particular interest that may be ascertained by the subject invention include carbohydrate metabolism diseases, autoimmune diseases, neoplasia, toxic chemical exposure and microbial infections. Fluorophore assisted carbohydrate electrophoresis diagnosis may be applied to various patient specimens, including blood, urine and skin.
Claims25
A method of diagnosing a disease by measuring labels of a diagnostic carbohydrate present in a sample containing a mixture of carbohydrates, said method comprising the steps:
- separating said diagnostic carbohydrate from other carbohydrates that may be present in said sample by fluorophore assisted carbohydrate electrophoresis, and,
- comparing the quantity of at least one diagnostic carbohydrate present in said sample with the quantity of the same diagnostic carbohydrate present in a reference standard.
- wherein said sample is a patient sample, and the quantity of said standard is the quantity of said diagnostic carbohydrate present in a comparable sample from an individual with or without said disease.
Dependencies are inferred from the claim text.