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US 5,205,914 AGranted
Synthesis of desflurane
AssigneeAnaquest, Inc.
InventorsLeonid A. Rozov, Chialang Huang, Gerald G. Vernice
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Abstract
An improved preparation of desflurane, 1,2,2,2-tetrafluoroethyl difluoromethyl ether utilizing hexafluoropropene epoxide as a starting material. Hexafluoropropene epoxide is advantageous in that it is relatively inexpensive and is environmentally acceptable.
Claims10
A process for the preparation of 1,2.2,2-tetrafluoroethyl difluoromethyl ether comprising:
- (a) reacting hexafluoropropene epoxide with methanol to yield methyl 2-methoxytetrafluoropropionate;
- (b) hydrolyzing the product of step (a) to form 2-methoxytetrafluoropropionic acid;
- (c) decarboxylating said acid to form 1,2,2,2-tetrafluoroethyl methyl ether;
- (d) chlorinating said ether to form CF.sub.3 CFHOCHCl.sub.2 ;
- and
- (e) reacting the product of step (d) with a fluorinating agent to form 1,2,2,2-tetrafluoroethyl difluoromethyl ether.
3 more elements
Dependencies are inferred from the claim text.