US 5,204,482 A · Compounds for treating and preventing cognitive diseases and depression and methods of making same

Abstract

Ethylenediamine monoamides of the formula R--CO--NH--CH.sub.2 --CH.sub.2 --NH.sub.2 I wherein R is one of groups ##STR1## in which R.sup.1 is phenyl, monohalophenyl, monolower-alkylphenyl, monolower-alkoxyphenyl, monotrifluoromethylphenyl, monocyanophenyl or monaryl-lower-alkoxyphenyl, dihalophenyl, furyl, thienyl or monohalothienyl, R.sup.2 is hydrogen, halogen or amino, R.sup.3, R.sup.5 and R.sup.7 each are phenyl, monohalophenyl, dihalophenyl, thienyl, furyl or monohalofuryl, R.sup.4 and R.sup.6 each are hydrogen or amino and R.sup.8 is hydrogen or lower-alkyl, as well as their pharmaceutically usable acid addition salts are disclosed. The compounds have monoamine oxidase inhibiting properties with low toxicity and are useful for the treatment of depressive states and cognitive disorders.

Claims3

Dependent claims

A compound of formula R--CO--Y wherein R is one of the groups ##STR5## and Y is a group --NH--CH.sub.2 --CH.sub.2 --R.sup.14 ;

in which R.sup.1 is phenyl, monohalophenyl, monolower-alkylphenyl, monocyanophenyl, monoaryl-lower-alkoxyphenyl, dihalophenyl, furyl, thienyl or monohalothienyl;
R.sup.2 is hydrogen, halogen or amino;
R.sup.3, R.sup.5 and R.sup.7 each independently are phenyl, monohalophenyl dihalophenyl, thienyl, furyl or monohalofuryl;
R.sup.4 and R.sup.6 each are hydrogen or amino;
R.sup.8 is hydrogen or lower-alkyl;
and
R.sup.14 is a leaving group selected from the group consisting of halogen, arylsulfonyloxy and alylsulfonyloxy.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

07/650,320Filed 4 Feb 1991 · division

Priority

CH 2871/8828 Jul 1988

Granted

20 Apr 1993

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 413/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
C07D 231/14
Having two or three double bonds between ring members or between ring members and non-ring members: with hetero atoms or with carbon atoms having…
C07D 261/18
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C07D 263/34
Having two or three double bonds between ring members or between ring members and non-ring members: with hetero atoms or with carbon atoms having…

Compounds for treating and preventing cognitive diseases and depression and methods of making same

Life of this patent

Compounds for treating and preventing cognitive diseases and depression and methods of making same

Life of this patent

Abstract

Claims3