High bulk density, crystalline 3-cyano-2-morpholino-5-pyrid-4-yl)-pyridine

Abstract

A method for preparing high bulk density crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine which comprises precipitating a high bulk density crystaline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine from a starting material that is (a) a solution in an inorganic or organic acid, and precipitating with a base, or (b) a solution in a chlorinated hydrocarbon, and precipitating with an aliphatic hydrocarbon, or (c) from an aliphatic ester of an aliphatic carboxylic acid and an aliphatic alcohol. The compact, crystalline 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine, so obtained, has a bulk density of from about 220 to about 360 g/l and is most suitable for pharmaceutical preparations.

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