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US 5,204,463 AGranted
Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities
AssigneeGlaxo Inc.
InventorsThomas N. Wheeler, Terrence P. Kenakin, Joel E. Shaffer
Life of this patent
Estimating the term…
Abstract
Pyridazinones of the following formula (I): ##STR1## where R.sup.1 -R.sup.4 are a variety of substituents and L is a linking group, a pharmaceutical composition for treating congestive heart failure, novel intermediates, methods for such treatment and processes for preparing compounds of formula (I).
Claims8
A pyridazinone of the following formula (I):
- ##STR9## wherein:
- R.sup.1 represents hydrogen or lower alkyl;
- R.sup.2 represents hydrogen, halogen, trifluoromethyl, cyano, lower alkyl, or lower alkyloxy;
- L represents a linking-moiety of the formula (II) or (III):
- ##STR10## in which:
- R.sup.5 -R.sup.11 represent, independently, hydrogen or lower alkyl;
- n represents the integer 1, 2 or 3;
- p represents the integer 2, 3, 4, 5, or 6;
- R.sup.3 represent morpholino and R.sup.4 represents hydrogen;
- wherein:
- said lower alkyl is of 1 to about 3 carbons,
- or a pharmaceutically acceptable acid-addition salt thereof.
9 more elements
The compound 6-{4-[N-[2-[3-(2-morpholinophenoxy)-2-hydroxy-propylamino]ethyl]carbamoylm ethoxyphenyl]}-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
Dependencies are inferred from the claim text.