Ruthenium catalyzed process for preparing 4-acetoxyazetidinones
AssigneeTakasago International Corporation
InventorsTakao Saito, Hidenori Kumobayashi
Life of this patent
Estimating the term…
Abstract
A simplified process for preparing 4-acetoxyazetidinones of formula (I): ##STR1## wherein Z is a hydrogen atom, a lower alkyl group or a hydroxyethyl group which may or may not be protected is disclosed. According to the invention, azetidinones of formula (II): ##STR2## wherein Z has the same meaning as defined above and Y is a hydrogen atom or a carboxyl group is reacted with acetic acid and an oxidizing agent in the presence of a ruthenium compound represented by the formula [Ru(B).sub.2 (L)].sub.m wherein B is Cl, Br or l, m is a positive integer, and L is 1,5-cyclooctadiene, norbornadiene, cycloheptatriene, cyclooctatetraene or benzene which may or may not have a lower alkyl group as a substituent, as a catalyst.
Claims2
A process for preparing 4-acetoxyazetidinones of the following formula (I):
- ##STR15## wherein Z is a hydrogen atom, a lower alkyl group or a hydroxyethyl group which may or may not be protected, which comprises reacting the following three components (a), (b) and (c):
- (a) azetidinones of formula (II):
- ##STR16## wherein Z has the same meaning as defined above and Y is a hydrogen atom or a carboxyl group,
- (b) acetic acid, and
- (c) oxidizing agent,
- in the presence of a ruthenium compound as a catalyst represented by [Ru(B).sub.2 (L)].sub.m wherein:
- B is Cl, Br or l;
- m is a positive integer, and
- L is 1,5-cyclooctadiene, norbornadiene, cycloheptatrien, cyclooctatetraene or benzene which may or may not have a lower alkyl group as a substituent.
Dependencies are inferred from the claim text.