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US 5,204,373 AGranted
Farnesylated tetrahydro-naphthalenols as hypolipidemic agents
AssigneeBristol-Myers Squibb Company
InventorBradley C. Pearce
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Abstract
The invention relates to novel farnesylated tetrahydro-naphthalenols, that inhibit HMGR activity which results in a decrease in serum total cholesterol, a decrease in LDL cholesterol levels, and inhibition of LDL oxidation. The farnesylated tetrahydro-naphthalenols of the present invention are thus useful for cholesterol/lipid lowering in cases of hypercholesterolemia, hyperlipidemia, and atherosclerosis.
Claims9
The compound having the structural formula ##STR6## wherein R.sub.1 represents hydrogen, C.sub.1 -C.sub.10 alkyl, halogen, or OMe;
- R.sub.2 represents hydrogen, C.sub.1 -C.sub.10 alkyl;
- and n is 1-3,
- or pharmaceutically acceptable acid additional salts, metal salts, or solvates thereof.
Dependencies are inferred from the claim text.