Hetaryl styryl quinolines as leukotriene inhibitors

A compound of the formula:

• ##STR19## wherein:
• R.sup.1 is H, halogen, C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, --CF.sub.3, --SR.sup.2, --S(O)R.sup.2, --S(O).sub.2 R.sup.2, --OR.sup.3, --COOR.sup.3, --(C.dbd.O)R.sup.3, --C(OH)R.sup.3 R.sup.3, --CN, --N.sub.3, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, substituted or unsubstituted 2-phenethyl, or substituted or unsubstituted pyridyl;
• R.sup.2 is C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, --CF.sub.3, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, or substituted or unsubstituted 2-phenethyl;
• R.sup.3 is H or R.sup.2 ;
• R.sup.4 is H, halogen, --NO.sub.2, --CN, --OR.sup.3, --SR.sup.3, NR.sup.3 R.sup.3, or C.sub.1 -C.sub.8 alkyl;
• R.sup.5 is H, halogen, --N.sub.3, --CN, --SR.sup.2, --NR.sup.3 R.sup.3, --OR.sup.3, C.sub.1 -C.sub.8 alkyl, --(C.dbd.O)R.sup.3 ;
• R.sup.6 is --CH.sub.2 CONR.sup.12 R.sup.12 ;
• R.sup.7 is H or C.sub.1 -C.sub.4 alkyl;
• R.sup.10 is --SR.sup.11, --OR.sup.12, or --NR.sup.12 R.sup.12 ;
• R.sup.11 is C.sub.1 -C.sub.6 alkyl, --(C.dbd.O)R.sup.14, unsubstituted phenyl, or unsubstituted benzyl;
• R.sup.12 is H or R.sup.11 ;
• R.sup.13 is C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, --CF.sub.3, or unsubstituted phenyl, benzyl, or 2-phenethyl;
• R.sup.14 is H or R.sup.13 ;
• R.sup.15 is R.sup.3 or halogen;
• R.sup.16 is H, C.sub.1 -C.sub.4 alkyl, or OH;
• R.sup.17 is C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, or substituted or unsubstituted phenyl, benzyl, or 2-phenethyl;
• R.sup.18 is C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, --CF.sub.3, or substituted or unsubstituted phenyl, benzyl, or 2-phenethyl;
• R.sup.19 is C.sub.4 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 alkynyl, --CF.sub.3, or unsubstituted phenyl, benzyl, or 2-phenethyl;
• m and m' are independently 0-8;
• n and n' are independently 0 or 1 but not both 0;
• p and p' are independently 0-8;
• m+n+p is 1-10 when X.sup.2 is O, S, S(O), or S(O).sub.2 ;
• m+n+p is 0-10 when X.sup.2 is CR.sup.3 R.sup.16 ;
• m'+n'+p' is 1-10 when X.sup.3 is O, S, S(O), or S(O).sub.2 ;
• m'+n'+p' is 0-10 when X.sup.3 is CR.sup.3 R.sup.16 ;
• r is 0 or 1 when Z.sup.1 is HET (--R.sup.3, --R.sup.5);
• r is 1 when Z.sup.1 is --CONR.sup.3 ;
• r' is 0 or 1 when Z.sup.2 is HET(--R.sup.3, --R.sup.5);
• r' is 1 when Z.sup.2 is CONR.sup.3 ;
• Q.sup.1 and Q.sup.2 are independently --COOR.sup.3, tetrazole, --COOR.sup.6, --CONHS(O).sub.2 R.sup.13, --CN, --CONR.sup.12 R.sup.12, --CHO, --CH.sub.2 OH, --COCH.sub.2 OH, --NHS(O).sub.2 R.sup.13, --C(O)R.sup.19, --NR.sup.17 C(O)OR.sup.17, --NR.sup.12 C(O)NR.sup.12 R.sup.12, --NHC(O)R.sup.18, --OC(O)NHR.sup.12, --S(O).sub.2 R.sup.18, --S(O)R.sup.18, --S(O).sub.2 NR.sup.12 R.sup.12, --NO.sub.2, ##STR20## X.sup.1 is O, S, --S(O)--, --S(O).sub.2 --, --NR.sup.3, or --CR.sup.3 R.sup.3 --;
• X.sup.2 and X.sup.3 are independently O, S, S(O), S(O).sub.2, or CR.sup.3 R.sup.16 ;
• Y is --CR.sup.3 .dbd.CR.sup.3 --, --C.dbd.C--, --CR.sup.3 R.sup.3 --X.sup.1 --, --X.sup.1 --CR.sup.3 R.sup.3 --, --CR.sup.3 R.sup.3 --X.sup.1 --CR.sup.3 R.sup.3, ##STR21## Z.sup.1 and Z.sup.2 are independently --CONR.sup.3 --or --HET(--R.sup.3, --R.sup.5)--, provided that at least one of them is --HET(--R.sup.3, --R.sup.5)--;
• HET is ##STR22## substituted phenyl, benzyl, or 2-phenethyl mean 1 or 2 substituents on the aromatic ring selected from C.sub.1 -C.sub.6 alkyl, R.sup.10, NO.sub.2, SCF.sub.3, halogen, --COR.sup.7, --COR.sup.10, CN, and CF.sub.3 ;
• and the pharmaceutically acceptable salts thereof.