Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists

A compound of the formula:

• ##STR35## and the pharmaceutically acceptable salts thereof, wherein R is H or C.sub.2-5 alkylsulfonylalkyl,
• R.sup.1 is hydrogen,
• R.sup.2 is one of N-(R.sup.3).sub.2, Het-R.sup.4 or Alk-R.sup.5, wherein
• R.sup.3 is independently one or more of hydrogen, cycloalkyl, pyrrolidinyl substituted by oxo, carboxyalkyl or alkoxycarbonyalkyl, alkyl substituted by alkylamino, alkylcarbamate, alkylcarbonyl, alkylsulfonyl, alkylthio, alkoxycarbonyl, amino, aminocarbonyl, carboxyl, dialkylamino, dialkylaminoaryl, hydroxyl, sulfhydryl, or substituted or unsubstituted 5 or 6 membered heterocyclic rings having 1 or 2 heteroatoms where said heteroatom is N and said ring substituent is aralkoxycarbonyl;
• Het is a 5 or 6 membered heterocyclic ring having 1 or 2 heteroatom wherein said heteroatom is N,
• R.sup.4 is alkylsulfonyl, alkylsulfonylamino, alkylsulfonyloxy, alkylaminocarbonyl, alkylcarbamatealkylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl, aminocarbonylalkyl, aminoalkylcarbonyl, aralkoxycarbonyl, carbonyl, dialkylaminocarbonyl, dialkylaminoalkylcarbonyl, diaminoalkylcarbonyl, halogenalkyl, halogenalkylcarbonyl, halogenalkoxycarbonyl, hydroxy, hydroxyalkyl, hydroxyalkylcarbonyl, imidazolylalkylcarbonyl imidizinylalkylcarbonyl, or phthalimidinylalkyl;
• with the proviso for Het-R4 that Het cannot be mono-substituted by any one of the alkoxycarbonyl, alkoxycarbonylalkyl, aralkoxycarbonyl or hydroxy;
• Alk is alkyl,
• R.sup.5 is independently one or more of R.sup.6, or Het-R.sup.7 wherein R.sup.6 is independently one or more of alkylcarbamate, alkylcarbonylamino substituted by substituted imidazolyl or pyrrolidinyl rings where said ring substituent is alkyl or alkoxycarbonylalky, alkylcarbamatecycloalkyl, alkylcarbonylaminoalkylsulfonyl, alkylimidazolylthio, alkylimidizinylthio, alkylimidazolylalkylthio, alkylimidizinylalkylthio, alkylpyrrolidinylthio, alkylpyrrolidinylalkylthio, alkylsulfonyl, alkylsulfonylamino, alkylsulfonylalkylamino, alkoxycarbonyl, alkoxycarbonylalkylamine, alkoxycarbonylalkylcarbonylamine, alkoxycarbonylalkylsulfonylamine, amino, aminocarbonyl, aminoalkylcarbonylamino, aminocarbonylalkylsulfonyl, aminocarbonylalkylecarbonylamino, aralkoxy, aralkoxycarbonyl, aralkylcarbamate, arylcarbamate, arylcarbamatecarbonylamino, arylcarbamatealkylcarbonylamino, carboxyalkylamino, carboxyalkylcarbonylamino, carboxyalkylsulfonylamino, cyano, cyanoalkylcarbonylamino, dialkylaminoalkylcarbonylamino or oxo, with the proviso for R.sup.6 that R.sup.6 cannot be mono-substituted by any one of alkoxycarbonyl, alkylcarbamate, alkylsulfonyl, aralkylcarbamate, aralkoxy, amino, aminocarbonyl, or oxo;
• Het is as defined before;
• R.sup.7 is one or more of alkyl, imidazolinylalkylcarbonyl, imidazolinylalkylcarbonylamino, oxo, pyrrolidinylalkylcarbonyl, pyrrolidinylalkylcarbonylamino or alkylamino substituted by one or more of alkylcarbamate, alkylcarbamatealkylcarbonyl, alkylsulfonylalkyl, amino, aralkoxyalkyl or oxo with the proviso for Het-R.sup.7 that Het cannot be mono-substituted by alkyl alkylamino, dialkylamino or oxo.