Heterocyclic compounds and anticancer-drug potentiaters conaining them as effective components

A compound of the formula [II] ##STR23## in which A.sup.5 represents an oxygen or sulfur atom or an amino or NR.sup.3 group, which is bound to any available position on the condensed ring;

• B.sup.5 represents --CO(CH.sub.2).sub.n --;
• C.sup.5 represents ##STR24## D.sup.5 represents ##STR25## C.sup.5 and D.sup.5 together form ##STR26## E.sup.5, F.sup.5, G.sup.5 each represent a carbon atom, R.sup.1 and R.sup.2 each independently represent a hydrogen or halogen atom, a lower alkyl group, amino group, lower alkyl amino group, lower dialkyl amino group, a lower alkoxy, lower alkylthio, lower alkylsulfonyl, trifluoromethyl, cyano, nitro, amide or hydroxy group, wherein R.sup.1 and R.sup.2 may be on any position available on the condensed ring or one each on each of the rings or both on the same ring of which the condensed ring is formed;
• R.sup.3 represents a hydrogen atom or a lower alkyl, lower alkanoyl or benzoyl group;
• R.sup.5 and R.sup.6 each independently represent a hydrogen atom, or a lower alkyl or hydroxyalkyl group;
• R.sup.7, R.sup.8 and R.sup.9 each independently represent a hydrogen atom or a hydroxy, phenyl, pyridyl, halogenophenyl, alkylphenyl, alkoxyphenyl, aminophenyl, alkylaminophenyl, acylaminophenyl, or hydroxyphenyl group, I.sup.5, represents an oxygen atom ##STR27## or a nitrogen atom;
• J.sup.5 represents --(CH.sub.2).sub.m --, --CH.dbd.CH--, OCH.sub.2 -- or an oxygen atom, n is 1, 2, 3, 4 or 5 and m is 0, 1 or 2, or a pharmaceutically acceptable salt thereof.

A compound of the formula [III] ##STR28## in which A.sup.7 represents an oxygen or sulfur atom or an amino or NR.sup.3 group, which is bound to any available position on the condensed ring;

• B.sup.7 represents --(CH.sub.2).sub.n --, ##STR29## or C.sup.7 represents ##STR30## D.sup.7 represents ##STR31## E.sup.7, F.sup.7, G.sup.7 each represent a carbon atom, R.sup.1 and R.sup.2 each independently represent a hydrogen or halogen atom, a lower alkyl group, amino group, lower alkyl amino group, a lower dialkyl amino group, a lower alkoxy, lower alkylthio, lower alkylsulfonyl, trifluoromethyl, cyano, nitro, amide or hydroxy group, wherein R.sup.1 and R.sup.2 may be on any position available on the condensed ring or one each on each of the rings or both on the same ring of which the condensed ring is formed;
• R.sup.3 represents a hydrogen atom or a lower alkyl, lower alkanoyl or benzoyl group;
• R.sup.4 represents a hydroxyl, lower alkylamino, lower alkoxyl or lower acyloxy group;
• R.sup.5 and R.sup.6 each independently represent a hydrogen atom or a lower alkyl or hydroxyalkyl group;
• R.sup.7, R.sup.8 and R.sup.9 each independently represent a hydrogen atom or a hydroxy, phenyl, pyridyl, halogenophenyl, alkylphenyl, alkoxyphenyl, aminophenyl, alkylaminophenyl, acylaminophenyl, or hydroxyphenyl group, I.sup.7 represents an oxygen atom, ##STR32## or a nitrogen atom;
• J.sup.7 represents --(CH.sub.2).sub.m --, --CH.dbd.CH--, OCH.sub.2 -- or an oxygen atom, n is 1, 2, 3, 4 or 5 and m is 0, 1 or 2, or a pharmaceutically acceptable salt thereof.

A compound of the formula [IV] ##STR33## in which A.sup.9 represents an oxygen or sulfur atom or an amino or NR.sup.3 group, which is bound to any available position on the condensed ring;

• B.sup.3 represents --(CH.sub.2).sub.n --, ##STR34## or C.sup.9 represents ##STR35## D.sup.9 represents ##STR36## C.sup.9 and D.sup.9 can together form ##STR37## E.sup.9, F.sup.9, G.sup.9 each represent a carbon atom, R.sup.1 and R.sup.2 each independently represent a hydrogen or halogen atom, a lower alkyl group, amino group, lower alkyl amino group, lower dialkyl amino group, a lower alkoxy, lower alkylthio, lower alkylsulfonyl, trifluoromethyl, cyano, nitro, amide or hydroxy group, wherein R.sup.1 and R.sup.2 may be on any position available on the condensed ring or one each on each of the rings or both on the same ring of which the condensed ring is formed;
• R.sup.3 represents a hydrogen atom or a lower alkyl, lower alkanoyl or benzoyl group;
• R.sup.4 represents a hydroxyl, lower alkylamino, lower alkoxyl or lower acyloxy group;
• R.sup.5 and R.sup.6 each independently represent a hydrogen atom or a lower alkyl or hydroxyalkyl group;
• R.sup.7 and R.sup.8 each independently represent a hydrogen atom or a hydroxy, phenyl, pyridyl, halogenophenyl, alkylphenyl, alkoxyphenyl, aminophenyl, alkylaminophenyl, acylaminophenyl, or hydroxyphenyl;
• group R.sup.9 represents a pyridyl group;
• I.sup.9 represents an oxygen atom, ##STR38## or a nitrogen atom;
• J.sup.9 represents --(CH.sub.2).sub.m --, --CH.dbd.CH--, OCH.sub.2 -- or an oxygen atom, n is 1, 2, 3, 4 or 5 and m is 0, 1 or 2, or a pharmaceutically acceptable salt thereof.