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US 5,204,346 AGranted
Pyrazolopyridine compounds
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsYouichi Shiokawa, Atsushi Akahane, Hirohito Katayama, Takafumi Mitsunaga
Life of this patent
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Abstract
There are disclosed 3 [2(substituted alkyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-aryl pyrazolo [1,5-a]-pyridines useful for treating maladies requiring an adenosine antagonist, and preparative processes.
Claims5
A pyrazolopyridine compound of the formula:
- ##STR9## wherein R.sup.1 is phenyl, and R.sup.2 is amino(lower)alkyl;
- lower alkylamino(lower)alkyl;
- di(lower)alkylamino(lower)alkyl;
- carboxy(lower)alkylamino(lower)alkyl;
- protected carboxy(lower)alkylamino(lower)alkyl;
- lower alkylamino(lower)alkyl substituted by hydroxy and naphthyloxy;
- protected amino(lower)alkyl;
- cyano(lower)alkyl;
- cyano(higher)alkyl;
- heterocyclic substituted (lower)alkyl wherein heterocyclic is a substituted or unsubstituted heterocyclic group selected from the group consisting of pyridyl, tetrazolyl, piperidyl, piperazinyl, morpholinyl, oxazolidinyl and tetrahydropyranyl, in which said substituent(s) are 1 to 3 substituents independently selected from the group consisting of hydroxy(lower)alkyl, phenyl, (lower)alkoxyphenyl, and oxo;
- tetrazolyl(higher)alkyl;
- substituted tetrazolyl(higher)alkyl wherein the substituent is selected from the group consisting of hydroxy(lower)alkyl, oxo, phenyl, and (lower)alkoxyphenyl;
- phenyl(lower)alkyl;
- lower alkenyl;
- or dihydrochromenyl which is unsubstituted or substituted by 1 to 4 substituent(s) independently selected from the group consisting of lower alkyl, hydroxy and cyano, and wherein (lower)alkyl has 1 to 6 carbon atoms and (higher)alkyl has 7 to 20 carbon atoms.
12 more elements
Dependencies are inferred from the claim text.