6-epifumagillols and the pharmaceutical use thereof

A compound of the formula:

• ##STR6## wherein R.sup.1 is 2-methyl-1-propenyl group or isobutyl group;
• R.sup.2 is (1) hydrogen atom;
• (2) a C.sub.1-20 alkanoyl which may be substituted with an amino, hydroxyl, halogen or carboxyl;
• (3) a benzoyl or naphthoyl which may be substituted with a C.sub.2-6 alkyl, amino, halogen, hydroxyl, C.sub.1-6 alkoxy, cyano, carbamoyl or carboxyl;
• (4) a 2-furoyl, 2-thienoyl, nicotinoyl, isonicotinoyl, or imidazole-1-carbonyl group which may be substituted with a C.sub.2-6 alkyl, amino, halogen, hydroxyl, C.sub.1-6 alkoxy, cyano, carbamoyl or carboxyl;
• (5) a carbamoyl which may be substituted with a C.sub.1-6 alkyl, C.sub.1-6 alkanoyl, chloroacetyl, dichloroacetyl, trichloroacetyl, C.sub.1-6 alkoxycarbonylmethyl, carboxymethyl, phenyl, naphthyl or benzoyl, or form a cyclic amino group together with the adjacent nitrogen atom selected from the group consisting of pyrrolidino, piperidino, morpholino, piperazino or 4-phenylpiperazino;
• (6) a C.sub.1-6 alkoxycarbonyl which may be substituted with an amino, hydroxyl, halogen or carboxyl;
• (7) a phenoxycarbonyl which may be substituted with a C.sub.1-6 alkyl or halogen;
• (8) a benzenesulfonyl which may be substituted with one to three substituents selected from a C.sub.1-6 alkyl and halogen;
• (9) a C.sub.1-6 alkylsulfonyl which may be substituted with an amino, hydroxyl, halogen or carboxyl;
• or
• (10) a sulfamoyl which may be substituted with a C.sub.1-6 alkyl or phenyl, or a salt thereof.