Penetration enhancers for transdermal delivery of systemic agents
AssigneeWhitby Research, Inc.
InventorsGevork Minaskanian, James V. Peck, Vithal J. Rajadhyaksha
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Abstract
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein X is selected from the group consisting of oxygen and sulfur; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-17 and R is --CH.sub.3 ; wherein R is H or a lower alkyl group, m is 5-7 and n is 0-17.
Claims8
In a method for topically administering systemically active agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation, the improvement comprising the topical administration of an effective amount of a membrane penetration enhancer having the structural formula:
- ##STR3## wherein R' is hydrogen or a lower alkyl group having 1-4 carbon atoms;
- m is 2-6;
- and n is 0-17.
Dependencies are inferred from the claim text.