Oxalylamino acid derivatives and their use as medicaments for inhibiting proline hydroxylase

A method for the treatment of disorders of the metabolism of collagen and collagen-like substances comprising administering an effective amount of an oxalylamino acid compound or physiologically tolerable salt thereof, of the formula I ##STR5## in which R and R' are identical or different and are C.sub.1 -C.sub.6 alkyl or hydrogen,

• R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl,
• R.sup.2 is hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.3 -alkoxy, carboxyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, aryl, SH, NH.sub.2 or halogen, where the alkyl radicals are unsubstituted or substituted by aryl, OH, SH or NH.sub.2
• or
• R.sup.1 and R.sup.2 together are a C.sub.2 -C.sub.4 -alkylene chain.

A pharmaceutical composition comprising an effective amount of an oxalylamino acid compound or physiologically active salt thereof, of the formula I ##STR6## in which R and R' are identical or different and are Na, K or hydrogen,

• R.sup.1 is C.sub.1 -C.sub.4 -alkyl,
• R.sup.2 is C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.3 -alkoxy, carboxyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, aryl, SH, NH.sub.2 or halogen, where the alkyl radicals are unsubstituted or substituted by aryl, OH, SH or NH.sub.2
• or
• R.sup.1 and R.sup.2 together are a C.sub.2 -C.sub.4 -alkylene chain, in a compatible pharmaceutical carrier.