Antifungal compounds

A compound of formula (I) or a pharmaceutically acceptably salt thereof:

• ##STR46## wherein R.sub.1 is selected from the group consisting of a group --CH.sub.2 --X where X is hydrogen, halogen, --CN, --N.sub.3, --OC(O)R.sub.5, --S(O).sub.n R.sub.5, --SH, --OC(O)NHR.sub.5, --NHCONHR.sub.5 or --NR.sub.6 R.sub.7, where R.sub.5 is hydrogen, C.sub.1-8 alkyl, phenyl, naphthyl, heteroaryl, aryl-C.sub.1-4 alkyl or heteroaryl-C.sub.1-4 alkyl in each of which the aromatic moiety is optionally substituted with the proviso that when X is --S(O).sub.n R.sub.5, R.sub.5 does not represent hydrogen, R.sub.6 and R.sub.7 are independently hydrogen or C.sub.1-6 alkyl, or one of R.sub.6 and R.sub.7 is hydrogen and the other is -formyl, C.sub.2-8 alkanoyl, dialkoxyphosphoryl, aroyl, heteroaroyl, aryl-C.sub.1-4 alkanoyl, heteroaryl-C.sub.1-4 alkanoyl, C.sub.1-8 alkylsulphonyl, arylsulphonyl, heteroarylsulphonyl, aryl-C.sub.1-4 alkylsulphonyl or heteroaryl-C.sub.1-4 alkylsulphonyl, where n is 0, 1 or 2 and any R.sub.5 C.sub.1-8 alkyl and R.sub.5, R.sub.6 or R.sub. 7 aryl or heteroaryl moieties are optionally mono-, di-, or tri-substituted by any function selected from the group consisting of carboxy, nitro, alkoxycarbonyl, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen and NR.sub.6 R.sub.7 ;
• R.sub.2 is hydroxy or C.sub.1-8 alkoxy;
• R.sub.3 is an amino group or an acyl derivatives thereof, selected from the group consisting of N-D-lysyl, N-D-ornithyl, guanidine and N-glycosyl;
• and each R.sub.4 is hydrogen.