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US 5,204,258 AGranted
Gene expressing VPT protein and vectors expressing this protein
AssigneeDana-Farber Cancer Institute, Inc.
InventorsWilliam A. Haseltine, Eric Cohen
Life of this patent
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Abstract
Viral protein T from Human Immunodeficiency Virus Type 1 (HIV-1) is disclosed. The protein has a molecular weight of approximately 17 kD and is produced by the vpt gene of HIV-1. This protein is antigenic. Vectors capable of expressing the vpt protein are also described.
Claims7
A DNA segment containing a functional vpt gene but not the entire HIV genome, wherein the DNA segment will not express functional tat protein having the ability to trans-activate.
A vector containing:
- (a) a nucleotide segment containing a sufficient number of nucleotides corresponding to a region extending from the tat initiation codon and extending through the T open reading frame of the HIV genome, to express viral protein T, wherein the T open reading frame is in the same reading frame as the tat initiation codon wherein the vector will not express functional tat protein having the ability to trans-activate, and wherein the vector does not contain the entire HIV genome;
- and
- (b) a protomer upstream of the nucleotide segment.
Dependencies are inferred from the claim text.