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US 5,204,256 AGranted
Process for the purification of plasminogen activator inhibitor 2 (PAI-2)
AssigneeBehringwerke Aktiengesellschaft
InventorsKlaus-Peter Radtke, Norbert Heimburger, Karlheinz Wenz
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Abstract
A process for the purification of plasminogen activator inhibitor 2 (PAI-2) including the steps of preincubating a PAI-2-containing solution with a compound which cleaves disulfide linkages, mixing the solution with a water-soluble acridine or quinoline base to precipitate impurities in the solution, and separating the precipitated impurities to obtain PAI-2 in purified form.
Claims12
A process for the purification of plasminogen activator inhibitor 2 (PAI-2), which comprises the steps:
- (a) preincubating a PAI-2-containing solution with a compound which cleaves disulfide linkages;
- (b) mixing said solution with a water-soluble acridine or quinoline base to precipitate impurities in the solution;
- and
- (c) separating the precipitated impurities to obtain PAI-1 in purified form.
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Dependencies are inferred from the claim text.