Hybrid tissue plasminogen activator/urokinase polypeptides
AssigneesSagami Chemical Research Center, Central Glass Company, Limited, Hodogaya Chemical Co., Ltd., Nippon Soda Co., Ltd., Nissan Chemical Industries, Ltd., Toyo Soda Manufacturing Co., Ltd.
InventorsMichito Tagawa, Masakatsu Wada, Masayuki Yamada, Midori Yokoyama, Naganori Numao
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Abstract
A hybrid plasminogen activator-like polypeptide comprising a polypeptide region responsible for an affinity to fibrin derived from a tissue plasminogen activator polypeptide and a polypeptide region responsible for an enzyme activity derived from a prourokinase polypeptide; a DNA segment coding for the hybrid polypeptide; plasmid containing the DNA segment; a microorganism transformed with the DNA; and a process for production of the hybrid polypeptide comprising culturing the microorganism and recovering the hybrid polypeptide from the cultured cells.
Claims5
The hybrid polypeptide HA20.
The hybrid polypeptide HA23.
The hybrid polypeptide HA13.
The hybrid polypeptide HPA21L.
The hybrid polypeptide HPA24L.
Dependencies are inferred from the claim text.