Back to results
US 5,204,249 AGranted
Process for the preparation of carebastine and similar materials
AssigneeMerck Patent GmbH
InventorsHarry Schwartz, Henning Bottcher
Life of this patent
Estimating the term…
Abstract
The invention relates to a novel process for the preparation of carebastine and similar materials from ebastine or terfenadine by oxidization using microorganisms. Carebastine and similar materials are used for the treatment of allergic disorders and as antihistamines.
Claims4
A process for the preparation of carebastine and similar materials comprising microbiologically oxidizing compounds of formula I:
- R--(C(CH.sub.3).sub.3 (I)
- wherein ##STR2## wherein any or all of the phenyl groups and/or piperidinyl groups is/are substituted by alkyl, alkoxy or halo and wherein alkyl portion has 1-6 carbon atoms;
- with a Cunninghamella blakesleeana or Cunninghamella elegans and recovering the oxidized product.
Dependencies are inferred from the claim text.