Pharmaceutical compositions and methods for treating the symptoms of overindulgence
AssigneeMcNeil-PPC, Inc.
InventorsWilliam J. Goldman, Thomas N. Gates
Life of this patent
Estimating the term…
Abstract
This invention relates to a pharmaceutical composition for treating the symptoms of overidulgence comprising an analgesic effective amount of acetaminophen or a non-steroidal anti-inflammatory drug and a gastric acid inhibiting effective amount of an H.sub.1 or H.sub.2 blocker, proton pump inhibitor or a combination thereof and methods of treating the symptoms of overindulgence comprising administering such pharmaceutical compositions.
Claims14
A pharmaceutical composition for treating the symptoms of overindulgence due to the excessive or inappropriate intake of food and/or alcoholic beverages comprising a therapeutically effective amount of an analgesic and a gastric acid inhibiting effective amount of a proton pump inhibitor wherein the therapeutically effective amount of the analgesic is selected from the group consisting of acetaminophen from 500 to 1000 mg per dose, ibuprofen from 200 to 400 mg per dose, naproxen from 200 to 500 mg per dose, fenoprofen from 200 to 600 mg per dose, ketoprofen from 50 to 300 mg per dose, meclofenamate from 50 to 400 mg per dose, mefenamic acid from 250 to 500 mg per dose, piroxicam from 10 to 20 mg per dose, indomethacin from 25 to 200 mg per dose, sulindac from 150 to 400 mg per dose, tolmetin from 200 to 1200 mg per dose and their pharmaceutically acceptable salts;
- in combination with an effective amount of the proton pump inhibitor omeprazole of from 60 to 500 mg per dose and its pharmaceutically acceptable salts.
A method of treating the symptoms of overindulgence due to the excessive or inappropriate intake of food and/or alcoholic beverages comprising administering to a patient suffering from the symptoms of overindulgence a combination pharmaceutical composition comprising a therapeutically effective amount of an analgesic and a gastric acid inhibiting effective amount of a proton pump inhibitor wherein the therapeutically effective amount of analgesic is selected from the group consisting of acetaminophen from 500 to 1000 mg per dose, ibuprofen from 200 to 400 mg per dose, naproxen from 200 to 500 mg per dose, fenoprofen from 200 to 600 mg per dose, ketoprofen from 50 to 300 mg per dose, meclofenamate from 50 to 400 mg per dose, mefenamic acid from 250 to 500 mg per dose, piroxicam from 10 to 20 mg per dose, indomethacin from 25 to 200 mg per dose, sulindac from 150 to 400 mg per dose, tolmetin from 200 to 1200 mg per dose and their pharmaceutically acceptable salts;
- in combination with an effective amount of a proton pump inhibitor selected from the group consisting of omeprazole from 60 to 500 mg per dose, and its pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.