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US 5,204,116 AGranted
Dosage form providing immediate therapy followed by prolonged therapy
AssigneeAlza Corporation
InventorsDavid E. Edgren, Gurdish K. Bhatti, Judy A. Magruder
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Abstract
A dosage form is disclosed comprising a first layer and a second layer. The first layer provides immediate therapy and comprises a drug stereoisomer and the second layer provides prolonged therapy and comprises a drug racemate.
Claims4
An improvement in a method for administering a drug to a patient in need of therapy, wherein the method comprises:
- (a) admitting orally into the patient a dosage form comprising:
- (1) a first layer comprising 0.10 ng to 500 mg of stereoisomer drug and from 1 wt % to 99 wt % of a hydroxypropylmethylcellulose;
- (2) a second layer comprising 1 mg to 650 mg of a racemic drug and 1 wt % to 99 wt % of a different hydroxypropylmethylcellulose;
- and wherein the improvement comprises:
- (b) releasing the stereoisomer drug over a period of instant release up to 1 hour from the first layer to provide instant stereoisomeric drug therapy to the patient;
- and,
- (c) releasing the racemic drug over a prolonged period up to 24 hours from the second layer to provide prolonged racemic drug therapy to the patient.
4 more elements
A method for administering a drug stereoisomer and a drug racemate to a patient in need of drug therapy, wherein the method comprises:
- (a) admitting a dosage form orally into the patient, said dosage form comprising
- (1) a first layer comprising 0.10 ng to 500 mg of a drug stereoisomer and from 1 wt % to 99 wt % of a pharmaceutically acceptable hydroxypropylcellulose;
- (2) a second layer comprising 1 ng to 650 mg of a drug racemate and from 1 wt % to 99 wt % of a pharmaceutically acceptable hydroxypropylmethylcelulose;
- (b) administering the drug stereoisomer over a short period of time from the first layer;
- (c) administering the drug racemate over a longer period of time from the second layer;
- whereby
- (d) therapy is provided to the patient over both a short period and a longer period of time.
4 more elements
Dependencies are inferred from the claim text.